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Grey’s Anatomy: 5 Ways Denny And Izzie Were Soulmates (& 5 They Were Never Meant To Be)

If only fans could tell showrunners which couples should promise each other forever and which ones can go their separate ways. Grey’s Anatomy is the kind of show where viewers can never agree on the best pairings or who should break up, but that’s part of the enjoyment factor of watching. The characters always keep viewers guessing.

This show is all about romance, and while there are many pairs that should have happened, there are also a lot of relationships that fans have strong feelings about. One such couple is Izzie Stevens (Katherine Heigl) and Denny Duquette (Jeffrey Dean Morgan). Are these two perfect, or do they have some real problems?

Soulmates: She Risks Her Career For Him

Izzie sitting on the floor in the hospital in Grey's Anatomy

Izzie Stevens is a fascinating character because she’s stubborn and she learns some hard lessons during her time on Grey’s Anatomy. When she cuts Denny’s LVAD wire, she risks her entire career and everything that she has worked so hard for.

Because she’s willing to take such a big step, it’s hard to see her and Denny as anything but soulmates. She wouldn’t do this for just anyone, after all.

Not Meant To Be: It’s Too Dangerous / Inappropriate

Izzie cries while hugging Denny's body in Grey's Anatomy

It’s easy to argue that Denny and Izzie aren’t meant to be, however, because their romance is too dangerous and inappropriate.

It’s definitely frowned upon for patients and doctors/interns to date, and it also seems like a weird time to be looking for love since saving lives is of utmost importance in a hospital. There are a lot of other people who would have been better suited for Izzie.

Soulmates: They’re Together Even After He Passes Away

Izzie-Denny-Greys-Anatomy

It was super sad when Denny passed away but once fans got over that tragedy, something pretty wild happened: Izzie was convinced that she could still be with Denny once he was gone. Yup, in that way.

While this is definitely odd, it’s also true that these two are together even after one of them dies. How could they not be soulmates after that?

Not Meant To Be: Izzie Seems Unstable When Talking About His Ghost

8 Izzie Cut Denny's LVAD

While Izzie is over the moon that she can see Denny’s spirit, it doesn’t make her look like a stable, steady person, let alone a doctor who can handle anything that happens at the hospital.

Because this situation makes Izzie irrational, it doesn’t seem possible to say that she’s “meant to be” with Denny. Something is off about this and she’s not acting normally.

Soulmates: They Bond Over A Tough Situation

Denny and Izzie in the hospital on Grey's Anatomy

Izzie says some funny things on the show but the fact that Denny ends up in the hospital with a heart problem is definitely no laughing matter.

It’s possible to view Izzie and Denny as soulmates because they bond during a tough situation. As a medical professional, she knows what he’s going through and that’s not something that should be taken lightly.

Not Meant To Be: They Barely Know Each Other

Denny Duquette flirts with Izzie after waking up from a coma in Grey's Anatomy

While Izzie gets totally swept up in her love story with Denny, the truth is that she barely knows him. She can’t think that she needs to be with him forever just because she cares for him when he’s in the hospital.

After all, this is her workplace, and he just happened to be there. These two just don’t seem like endgame.

Soulmates: It’s Very Romantic

Izzie keeps seeing Denny's ghost in Grey's Anatomy

Sure, there are practical reasons why two people would be each other’s soulmates. They get along well, they share common interests, they’ve been together for a while, etc.

But what about romance? Logically, Denny and Izzie don’t make much sense together. They have a chance meeting at the hospital and they haven’t been conventionally dating, going to dinner and a movie and meeting each other’s families. But their love story is definitely very sweet and moving, and that counts for something.

Not Meant To Be: She Sees Him Because Of Her Cancer

Alex holding sick Izzie

Just like Amelia’s brain tumor really affects her personality, Izzie acts a certain way because she has cancer. In this case, she sees Denny’s ghost because she’s actually very ill.

Would Izzie see him if she was healthy? Probably not, which just means that these two characters aren’t actually meant to be.

Soulmates: She Can’t Move On From Him Easily

An image of a smiling Izzie Stevens in Grey's Anatomy.

Derek and Meredith are always considered the gold standard of Grey’s Anatomy love stories, but Izzie has a pretty epic love life, too.

The truth is that she has a lot of trouble moving on from Denny. She even sees his ghost, after all, and becomes a nervous wreck. Seeing as how it’s so tough for her to let go, this could mean that Denny is the person she’s supposed to be with.

Not Meant To Be: Izzie And Alex End Up Together

Izzie and Alex argue in Grey's Anatomy

When Alex Karev leaves the show, he makes it clear that he and Izzie are going to be together. While fans weren’t necessarily over the moon or even on board with this creative call, that’s the way that things ended up.

If Izzie and Denny were soulmates, then Denny wouldn’t have died and they would be married with kids by now. Instead, Izzie had to be single so she could end up with her one true love, which is Alex Karev.

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