Grey’s Anatomy: Lexie Grey’s 10 Best Episodes

“Where The Wild Things Are” (Season 4, Episode 12)

Lexie and George became fast friends while she kept his secret that he was repeating his intern year. This friendship eventually turned into a one-sided crush, though the two did decide to move into an apartment together.

In “Where The Wild Things Are,” Lexie hilariously (and shamelessly) stole medical supplies and decor to fill her drabby apartment. When she bumped into Meredith in the hallway of the hospital, she revealed what she was doing and begged Meredith to let her get away with it. It was the first sign of awkward rebellion fans got to see from Lexie, and it made for an excellent b-plot in the episode.

“The Becoming” (Season 4, Episode 14)

As Lexie settled into her role as an intern at Seattle Grace, she tried harder and harder to impress her residents including her sister’s best friend, Cristina Yang.

In this episode, Lexie followed Cristina down to the morgue when she practiced surgery on cadavers in her spare time to heal from her breakup with Doctor Burke. In an attempt to bond with her resident, Lexie joined in as Cristina sang ‘Like A Virgin’ by Madonna, and it was one of the silliest moments in all of Grey’s, but one that was much appreciated amid the usual heartbreak and tragedy the show had to offer.

“All By Myself” (Season 5, Episode 10)

Season 5 was a bit of a breakthrough for Lexie Grey as she began to find her footing and make real friends and relationships at Seattle Grace. This included her relationship with Mark Sloan, one that took fans by surprise when it started in this episode.

After making the rounds interning in plastics, Meredith’s friend Sadie realized that Mark was developing a crush on the younger Grey. Lexie shrugged it off but eventually found herself crushing on him too, and showed up at his hotel room demanding to be taught by him. This led to the two of them sleeping together and the start of their secret, adorable relationship that gave Lexie a promising season 5 storyline.

“Stairway to Heaven” (Season 5, Episode 13)

Honestly, Lexie and Mark were the less dramatic version of Meredith and Derek, which is what made their relationship healthier and more bearable at times. They got fun storylines that weren’t filled with angst and bickering, but instead with hookup-related injuries resulting in doctor hospitalization.

This episode gave fans a peek into Lexie’s nurturing side, as she climbed into bed with Mark and stroked his hair to ease his pain. The hair stroke was used later in the series when Lexie was dying, bringing Mark and Lexie’s relationship full circle and allowing viewers to remember her kind nature years prior.

“I Will Follow You Into The Dark” (Season 5, Episode 17)

“I Will Follow You Into The Dark” was a big episode for Lexie Grey. She went from being Meredith’s mousy younger sister to standing up for herself and proving just how smart of a doctor she was going to be.

Mark and Derek got into a fight after the latter found out that Mark was seeing Lexie, resulting in a lot of animosity between the former friends. Lexie comforted Mark and apologized for breaking him, but he assured her that she was the one who put him back together. Additionally, this was the episode where Lexie solved the ‘Patient X’ case, confirming that the mystery patient (who was revealed to be Izzie Stevens) had cancer.

“PYT (Pretty Young Thing)” (Season 7, Episode 14)

The usual happy-go-lucky Lexie Grey was nowhere to be found in the episode where her father is admitted to the hospital accompanied by his much younger girlfriend.

Lexie’s disdain for her father’s girlfriend is a bit out of character for her, but that’s what makes this episode such a good one for her. Because she was usually the voice of reason and logic, it’s was interesting to watch her revert to a childlike jealously and anger. This also allowed for Meredith to act as a proper older sister for Lexie, as she informed her that she was being selfish and needed to grow up.

“Put Me In Coach” (Season 8, Episode 7)

For so much of the sixth and seventh seasons of Grey’s Anatomy Mark was chasing down Lexie, but season 8 was the first time viewers actually got to see Lexie jealous and envious of Mark in a romantic relationship.

At a baseball game between two Seattle hospitals, Lexie famously threw the ball right into Julia, Mark’s new girlfriend’s, chest after being heckled by her. The episode gave insight into Lexie’s competitive side and the indication that she might not have been as ‘over’ Mark as she had previously claimed to be.

“Let The Bad Times Roll” (Season 8, Episode 22)

Chyler Leigh had one of her best performances as Lexie Grey in the season 8 episode, “Let The Bad Times Roll.” In this episode, Lexie delivered a heartbreaking speech to Mark declaring her love for him even though he was seeing somebody else. She broke down and finally admitted with an emotional quote that she was “infected by Mark Sloan,” after what seemed like seasons of her denying her true feelings for him.

What makes this speech ten times sadder is the fact that Lexie and Mark meet their demise just a couple of episodes later, never getting the chance to make Lexie’s dreams of them being together come true.

“Breathe” (Season 17, Episode 10)

Almost 10 years after her character’s death, Chyler Leigh reprised her role as Lexie Grey in a season 17 episode that featured yet another Meredith dream sequence.

On Meredith’s dream beach, Lexie and Mark were happily reunited in the afterlife and offering her all kinds of good advice as to why she should live. Lexie shared how much she missed her older sister, and the two finally got proper closer given that Lexie passed away from the plane crash before Meredith could say goodbye. It was a beautiful, emotional reunion but a gift for fans to see Lexie Grey on their screens again nine seasons later.